4 posts tagged “breast cancer”

A very interesting article about cancer survivors and tweeting while undergoing therapy and recovery.  Anderson Medical Center has their own TWITTER page, along with lists of survivors who tweet in support of each other.  You can read the whole article here.

Social media on the Internet are empowering, engaging, and educating health care consumers and providers. While consumers use social media -- including social networks, personal blogging, wikis, video-sharing, and other formats -- for emotional support, they also heavily rely on them to manage health conditions.

The Internet has evolved from the information-retrieval of “Web 1.0” to “Web 2.0,” which allows people who are not necessarily technologically savvy to generate and share content. The collective wisdom harnessed by social media can yield insights well beyond the knowledge of any single patient or physician, writes report author Jane Sarasohn-Kahn. The outcome of this development is “Health 2.0” -- a new movement that challenges the notion that health care happens only between a single patient and doctor in an exam room.

Using examples, this report describes how the Web is becoming a platform for convening people with shared concerns and creating health information that is more relevant to consumers. Social networks, ranging from MySpace to specific disease-oriented sites, are proliferating so rapidly that new services are already under development to help health consumers navigate through the networks.

The report details how innovative collaborations online are changing the way patients, providers, and researchers learn about therapeutic regimens and disease management. It examines the benefits and concerns regarding Health 2.0 and it also includes an extensive listing of health media resources.

According to the report, the growing demand for transparency will drive the evolution of social media in health. A growing array of tools will become available that are increasingly mobile, as well as personal health data storage in commercial products like Microsoft Health Vault, Google Health, and others. The author concludes that the ongoing demands of a consumer-driven health marketplace will inspire innovation in applications that integrate clinical, financial, and ratings information.

The complete report is available here

In lieu of my survivorship from breast cancer, I like to keep abreast (no pun attended) on the latest research so I can bug my oncologist with endless questions.  This is a super article and important for not only myself, but future survivors.

PARIS (AFP) - Geneticists have identified a super gene which causes breast cancer to metastasise, the deadly process by which the disease spreads to other organs, according to a study released Wednesday.

Described by the US researchers as a "master regulator," the SATB1 gene alters the behaviour of at least 1,000 other genes within tumour cells, said the study, published in the British journal Nature.

When over-activated it makes cancer cells proliferate, and when neutralised the gene stops the cells from dividing and migrating, the study reported.

"SATB1 will be a remarkable target for cancer therapy," lead scientist Termumi Kohwi-Shigematsu of the Lawrence Berkeley National Laboratory in Berkeley, California, told AFP.

The findings could not only pave the way to diagnostic tools that show the likelihood of the disease spreading, she said, but to drugs that could prevent or treat metastasis in breast cancer as well.

Up to now, it was impossible to predict whether cancer cells in a tumour were destined to invade neighboring tissue, travel through the blood system and form secondary tumours elsewhere in the body.

But the SATB1 protein is just such a marker. A tumour in which it is activated "is destined to metastasise," said Kohwi-Shigematsu.

Metastasis is the overwhelming cause of death in patients with solid tumours. Less than 10 percent of women with metastatic breast cancer survive beyond a decade, and just over a quarter make it past five years.

SATB1's normal role in organising other genes -- especially related to T-cells that play a critical role in the immune system -- was already well known, thanks in part to pioneering research by Kohwi-Shigematsu in the 1990s.

The gene had also been identified in breast tumours.

But the new study is the first to establish that "SATB1 is both necessary and sufficient for breast cancer cells to become metastatic," she said.

In experiments on mice, Kohwi-Shigematsu and colleagues "knocked down", or deactivated, the SATB1 gene by removing certain RNAs in the tumour cells upon which the gene depends for multiplying.

Messenger RNAs are tiny strings of nucleotides -- the basic building blocks of DNA -- that ferry the blueprints for constructing proteins from DNA genes to the cell's ribosomes, the factories where proteins are made.

The results, compared to control mice also infected with human metastatic breast cancer cells, were dramatic.

Between 125 and 160 metastatic nodules formed in each lung of all the control mice. But in the rodents in which SATB1 was suppressed, the number was between zero and five.

Deliberately over-expressing the gene had the opposite effect, causing the cancer cells to rapidly reproduce and run amok.

Translating the study's findings into an effective treatment for cancer would require targeting only the tumours in which the SATB1 gene has become overly active.

A drug that blocked the gene throughout the body would compromise its critical -- and normal -- role in activating the immune system.

Kohwi-Shigematsu is working on a means for delivering an inhibitor via microscopic nanocapsules, and said trials on humans could start within a couple of years. Prognostic tools could be available within a year.

Kohwi-Shigematsu's research is part of a new wave of cancer studies focusing on the genetic origins of the disease.

Scientists have come to realise, she said, that there are gene expression patterns called prognosis signatures, genetic profiles found across primary tumours that have metastatic potential.

"And now we have identified the protein master regulator for metastatis," she said.

But the most basic question remains to be answered, she added. "What turns SATB1 on during the course of breast cancer progression? We just don't know."

According to the American Cancer Society, about 1.3 million women worldwide are diagnosed each year with breast cancer, and nearly half-a-million succumb to the disease.